I have tried so many times with so many champions and there are only few occasions that Corrupting Potion doesn’t work. That is when I play a AD champion that doesn’t worry much about defense and when mana is not a issue. Corrupting Potion better than starting items since the leftover Gold that would be spent on Health Potions for the other starting items are permanently lost upon use. Always use refillable. For AD champs Long Sword + Refillable Potion is a viable option. Doran’s Blade + Health Potion is another possible option for AD champs. Everywhere else just run Corrupting Potion. Try it and share the experience.